The Norwegian Zebrafish Platform at the Norwegian School of Veterinary Science was established as a National Technology Platform under the Functional Genomics Program, Research Council of Norway.

Aleström Lab, NVH

February 22nd, 2017

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About us

Oslo 22 Feb. 2017

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ZEBRAFISH MODEL IN FUNCTIONAL GENOMICS & EPIGENOMICS

The zebrafish group at NMBU Faculty of Veterinary Science, Department of Basic Sciences & Aquatic Medicine (BasAm), Aleström Zebrafish Lab (AZLab) founded the National Technology Platform (2008-2012) under the Functional Genomics Program (FUGE), Research Council of Norway. Since 2013 the Zebrafish Platform (zebrafish.no) is integrated together with other species of laboratory animals at NMBU Vet as part of Section for Experimental Biomedicine.

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Zebrafish (Danio rerio) is the second most used laboratory model species. Important in basic science for deciphering the genetic and molecular events underlying vertebrate embryo development and other biological processes and increasingly in biomedicine and toxicology and environmental science. See review article “Alestrom et al. 2006, Zebrafish in functional genomics and aquatic biomedicine”, Genialt 1-2013 and the link on zebrafish.no Home page: About the zebrafish model.

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RESEARCH

We focus on the zebrafish early embryo development at the level of genome wide gene expression analysis (transriptomics) and the epigenetic landscapes behind the gene expression (epigenomics with and DNA methylation and hydroxymethylation). The work has been carried out in close collaboration with internationally recognized groups in the field: Philippe Collas Lab at University of Oslo and Sinnakaruppan Mathavan at Genome Institute of Singapore. Small non-coding RNAome included in the epigenetic profiling of of early embryo development control as a collaboration with Igor Babiak at UiN, Bodø and John Postlethwait, University of Oregon.

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NMBU Vet and AZLab is Partner in Centre for Environmental RADiation (CoE CERAD; https://cerad.nmbu.no) 2013-2022. Effects on low dose gamma radiation, in combination with UV, climate factors and other multiple stressors is studied in several systems, at NMBU Vetbio using the zebrafish model. A main goal is to characterize molecular mechanisms as a basis for risk assessment. Differential gene expression and epigenetic mark analysis at DNA methylation/hydroxymethylation levels, histone post translational modification and ncRNA expression patterns are monitored and correlated to classical endpoints and transgenerational effects.

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Microgravity omics (µG-omics): AZLab participates in research on how exposures to µG effects gene expression and related epigenetic landscapes (European Space Agency, MAP Project AO-99-LSS-006 2014-2016) funded project aiming at exposing zebrafish for µG in a space shuttle: Professors Marc Müller (Univ. of Liege) and Silvia Bradamante (Univ. of Milan) are coordinators of this ESA-funded research project.

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EDUCATION

“e-ZFbook, a new concept for e-learning” (2015-2017): Professors Peter Aleström and Charles McLean Press has received a grant  from Olav Thon Stiftelsen to develop “e-ZFbook”.

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GROUP MEMBERS

  • Peter Aleström, Professor, Head of the zebrafish group (AZLab) and CERAD partner NMBU Vet.
  • Leonardo Martin Martin, DVM, PhD student, NMBU. ncRNA analysis. FishmiR and CERAD. 2013-2017.
  • Jorke Kamstra, MSc, PhD student, NMBU Vetbio/CERAD. DNAme/hme analysis. 2015-2018.
  • Leif C. Lindeman, Postdoc, zebrafish histone PTM epigenetics, NMBU/CERAD 2015-.
  • Erik Magne Koscielniak  Rasmussen, Chief engineer 2016-.
  • Viola Lobert, Postdoc, zebrafish colon cancer. NMBU Vetbio/Radiumhospitalet. 2015-.

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PARTNERS

  • CERAD consortium (Brit Salbu et al.; https://cerad.nmbu.no)
  • Jan Lyche, Department of Food Safety & Infection Biology, NMBU Vet.
  • Philippe Collas, Epigenomics and plutipotency control, Collas Lab., Univ. Oslo
  • Igor Babiak, FishmiR, University of Nordland
  • Erik Ropstad, Head for Section of Experimental Biomedicine, NMBU Vet.
  • Marc Müller, Microgravity genomics, ESA, ULg, Belgium.
  • Silvia Bradamante, Microgravity genomics, ESA, University of Milan, Italy.
  • Sinnakaruppan Mathavan, RNA-sequencing, GIS, Singapore.
  • Cecilia Winata, Postdoc, International Institute of Molecular and Cell Biology, Warsaw.
  • Mike Moulton, NMBU Learning Center
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CONTACT US: peter.alestrom@nmbu.no
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List of publications

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